NSC 66811

Catalog No. Size PriceQuantity
M12812-2 2mg solid $145
M12812-10 10mg solid $435


NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2.

Product information

CAS Number: 6964-62-1

Molecular Weight: 340.42

Formula: C23H20N2O

Chemical Name: 2-methyl-7-[phenyl(phenylamino)methyl]quinolin-8-ol

Smiles: CC1=CC=C2C=CC(C(NC3C=CC=CC=3)C3C=CC=CC=3)=C(O)C2=N1


InChi: InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (293.75 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53.


  1. Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62.
  2. Sanjeev Shangary, et al. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Annu Rev Pharmacol Toxicol. 2009;49:223-41.

Products are for research use only. Not for human use.

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