NSC 66811


Catalog No. Size PriceQuantity
M12812-2 2mg solid $145
M12812-10 10mg solid $435

Description

NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2.

Product information

CAS Number: 6964-62-1

Molecular Weight: 340.42

Formula: C23H20N2O

Chemical Name: 2-methyl-7-[phenyl(phenylamino)methyl]quinolin-8-ol

Smiles: CC1=CC=C2C=CC(C(NC3C=CC=CC=3)C3C=CC=CC=3)=C(O)C2=N1

InChiKey: WEENRMPCSWFMTE-UHFFFAOYSA-N

InChi: InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (293.75 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53.

References:

  1. Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62.
  2. Sanjeev Shangary, et al. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Annu Rev Pharmacol Toxicol. 2009;49:223-41.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed