CP-31398 dihydrochloride

Catalog No. Size PriceQuantity
M12814-2 2mg solid $145
M12814-10 10mg solid $435


CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

Product information

CAS Number: 1217195-61-3

Molecular Weight: 435.39

Formula: C22H28Cl2N4O

Chemical Name: N-[3-(dimethylamino)propyl]-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4-amine dihydrochloride

Smiles: Cl.Cl.COC1C=CC(/C=C/C2N=C3C=CC=CC3=C(NCCCN(C)C)N=2)=CC=1


InChi: InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells. CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells.

In Vivo:

CP-31398 (100 mg/kg, orally) exhibits significant anti-tumor activity in mice models.


  1. B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286(5449):2507-10.
  2. Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1(1):47-55.
  3. J Wischhusen, et al. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene. 2003 Nov 13;22(51):8233-45.

Products are for research use only. Not for human use.

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