NSC 146109 hydrochloride


Catalog No. Size PriceQuantity
M12815-2 2mg solid $115
M12815-10 10mg solid $345

Description

NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes.

Product information

CAS Number: 59474-01-0

Molecular Weight: 316.85

Formula: C17H17ClN2S

Chemical Name: {[(10-methylanthracen-9-yl)methyl]sulfanyl}methanimidamide hydrochloride

Smiles: Cl.CC1C2=CC=CC=C2C(CSC(N)=N)=C2C=CC=CC2=1

InChiKey: VIBMUYOXJUCEMA-UHFFFAOYSA-N

InChi: InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9.

Products are for research use only. Not for human use.

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