MA242

MA242 is a dual inhibitor of murine double minute 2 (MDM2) and nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy.

Product information

CAS Number: 1049704-18-8

Molecular Weight: 579.98

Formula: C26H21ClF3N3O5S

Chemical Name: 10-{[(4-chlorophenyl)methyl]amino}-2-(4-methylbenzenesulfonyl)-2, 7-diazatricyclo[6.3.1.0, ]dodeca-1(12), 3, 7, 9-tetraen-11-one; trifluoroacetic acid

Smiles: CC1C=CC(=CC=1)S(=O)(=O)N1C=C2CCN=C3C=C(NCC4C=CC(Cl)=CC=4)C(=O)C1=C23.OC(=O)C(F)(F)F

InChiKey: YTSFRIUMZUCDMV-UHFFFAOYSA-N

InChi: InChI=1S/C24H20ClN3O3S.C2HF3O2/c1-15-2-8-19(9-3-15)32(30,31)28-14-17-10-11-26-20-12-21(24(29)23(28)22(17)20)27-13-16-4-6-18(25)7-5-16;3-2(4,5)1(6)7/h2-9,12,14,27H,10-11,13H2,1H3;(H,6,7)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Wang W, et al. Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy. Cancer Res. 2018 Oct 1;78(19):5656-5667.

Products are for research use only. Not for human use.