Catalog No. Size PriceQuantity
M12819-2 2mg solid $125
M12819-10 10mg solid $375


NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.

Product information

CAS Number: 58131-57-0

Molecular Weight: 279.25

Formula: C11H13N5O4

Chemical Name: 7-(4-methylpiperazin-1-yl)-4-nitro-2, 1, 3-benzoxadiazol-1-ium-1-olate

Smiles: CN1CCN(CC1)C1=CC=C(C2=NO[N+]([O-])=C21)[N+]([O-])=O


InChi: InChI=1S/C11H13N5O4/c1-13-4-6-14(7-5-13)9-3-2-8(15(17)18)10-11(9)16(19)20-12-10/h2-3H,4-7H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NSC-207895 (0.5 μM, 30 min), a MDM2 inhibitor, upregulates p53 protein levels. NSC-207895, MDMX inhibitor, downregulates the expression of MDMX in AML cells at the mRNA and protein levels.


  1. Laura Kapitzky, et al. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451.
  2. Erdenezaya Odkhuu, et al. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B. Immunobiology. 2015 Jan;220(1):136-41.
  3. Luis A Carvajal, et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med. 2018 Apr 11;10(436):eaao3003.

Products are for research use only. Not for human use.

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