Catalog No. Size PriceQuantity
M12824-2 2mg solid $310
M12824-10 10mg solid $1,240


GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM.

Product information

CAS Number: 1601496-05-2

Molecular Weight: 377.49

Formula: C19H15N5S2



Chemical Name: 3-(1, 3-benzothiazol-5-yl)-7-(1, 3-dimethyl-1H-pyrazol-5-yl)thieno[3, 2-c]pyridin-4-amine

Smiles: CC1C=C(C2=CN=C(N)C3=C2SC=C3C2C=C3N=CSC3=CC=2)N(C)N=1


InChi: InChI=1S/C19H15N5S2/c1-10-5-15(24(2)23-10)12-7-21-19(20)17-13(8-25-18(12)17)11-3-4-16-14(6-11)22-9-26-16/h3-9H,1-2H3,(H2,20,21)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (132.45 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.

Products are for research use only. Not for human use.

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