Description
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis.
Product information
CAS Number: 64657-21-2
Molecular Weight: 410.50
Formula: C22H34O7
Synonym:
Coleonol B
Chemical Name: (3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-3-ethenyl-5, 10, 10b-trihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2, 1-b]pyran-6-yl acetate
Smiles: CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](OC(C)=O)[C@H](O)[C@@]1(C)O[C@](C)(CC(=O)[C@@]12O)C=C
InChiKey: CLOQVZCSBYBUPB-KGGHGJDLSA-N
InChi: InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Isoforskolin downregulates the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA).
References:
- Zhao H, et al. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A.Exp Ther Med. 2017 Dec;14(6):5974-5980.
Products are for research use only. Not for human use.
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