Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration.
CAS Number: 50335-03-0
Molecular Weight: 528.64
Chemical Name: (1R, 6R, 9S, 13R, 14S, 16R, 17S, 18R, 19S)-6-hydroxy-19-[(1H-indol-3-yl)methyl]-7, 9, 16, 17-tetramethyl-15-oxa-20-azatetracyclo[22.214.171.124, .0, ]henicosa-3, 7, 11-triene-2, 5, 21-trione
Smiles: C[C@]12O[C@H]1[C@@H]1C=CC[C@H](C)C=C(C)[C@@H](O)C(=O)C=CC(=O)[C@]31[C@H]([C@H](CC1=CNC4=CC=CC=C41)NC3=O)[C@@H]2C |c:11,t:6,18|
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
- Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98.
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