Chaetoglobosin A


Catalog No. Size PriceQuantity
M12881-2 2mg solid $830
M12881-10 10mg solid $3,320

Description

Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration.

Product information

CAS Number: 50335-03-0

Molecular Weight: 528.64

Formula: C32H36N2O5

Chemical Name: (1R, 6R, 9S, 13R, 14S, 16R, 17S, 18R, 19S)-6-hydroxy-19-[(1H-indol-3-yl)methyl]-7, 9, 16, 17-tetramethyl-15-oxa-20-azatetracyclo[11.8.0.0, .0, ]henicosa-3, 7, 11-triene-2, 5, 21-trione

Smiles: C[C@]12O[C@H]1[C@@H]1C=CC[C@H](C)C=C(C)[C@@H](O)C(=O)C=CC(=O)[C@]31[C@H]([C@H](CC1=CNC4=CC=CC=C41)NC3=O)[C@@H]2C |c:11,t:6,18|

InChiKey: OUMWCYMRLMEZJH-LAQBRKCOSA-N

InChi: InChI=1S/C32H36N2O5/c1-17-8-7-10-22-29-31(4,39-29)19(3)27-24(15-20-16-33-23-11-6-5-9-21(20)23)34-30(38)32(22,27)26(36)13-12-25(35)28(37)18(2)14-17/h5-7,9-14,16-17,19,22,24,27-29,33,37H,8,15H2,1-4H3,(H,34,38)/b10-7-,13-12-,18-14-/t17-,19-,22-,24-,27-,28+,29-,31+,32+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed