Chaetoglobosin A

Catalog No. Size PriceQuantity
M12881-2 2mg solid $830
M12881-10 10mg solid $3,320


Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration.

Product information

CAS Number: 50335-03-0

Molecular Weight: 528.64

Formula: C32H36N2O5

Chemical Name: (1R, 6R, 9S, 13R, 14S, 16R, 17S, 18R, 19S)-6-hydroxy-19-[(1H-indol-3-yl)methyl]-7, 9, 16, 17-tetramethyl-15-oxa-20-azatetracyclo[, .0, ]henicosa-3, 7, 11-triene-2, 5, 21-trione

Smiles: C[C@]12O[C@H]1[C@@H]1C=CC[C@H](C)C=C(C)[C@@H](O)C(=O)C=CC(=O)[C@]31[C@H]([C@H](CC1=CNC4=CC=CC=C41)NC3=O)[C@@H]2C |c:11,t:6,18|


InChi: InChI=1S/C32H36N2O5/c1-17-8-7-10-22-29-31(4,39-29)19(3)27-24(15-20-16-33-23-11-6-5-9-21(20)23)34-30(38)32(22,27)26(36)13-12-25(35)28(37)18(2)14-17/h5-7,9-14,16-17,19,22,24,27-29,33,37H,8,15H2,1-4H3,(H,34,38)/b10-7-,13-12-,18-14-/t17-,19-,22-,24-,27-,28+,29-,31+,32+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98.

Products are for research use only. Not for human use.

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