7, 8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7, 8-Dihydroneopterin can be used in the research of neurodegenerative diseases.
CAS Number: 1218-98-0
Molecular Weight: 255.23
Chemical Name: 2-amino-6-[(1S, 2R)-1, 2, 3-trihydroxypropyl]-3, 4, 7, 8-tetrahydropteridin-4-one
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
7, 8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y). 7, 8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes.
- C Speth, et al. Inflammation Marker 7,8-dihydroneopterin Induces Apoptosis of Neurons and Glial Cells: A Potential Contribution to Neurodegenerative Processes. Immunobiology. 2000 Nov;202(5):460-76.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.