Maduramicin ammonium

Maduramicin ammonium (Maduramycin ammonium) is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection. Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.

Product information

CAS Number: 84878-61-5

Molecular Weight: 934.16

Formula: C47H83NO17

Synonym:

Maduramycin ammonium

Chemical Name: 2H-Pyran-2-acetic acid, 6-((1R)-1-((2S, 5R, 7S, 8R, 9S)-2-((2S, 2'R, 3'S, 5R, 5'R)-3'-((2, 6-dideoxy-3, 4-di-O-methyl-beta-L-arabino-hexopyranosyl)oxy)octahydro-2-methyl-5'-((2S, 3S, 5R, 6S)-tetrahydro-6-hydroxy-2, 8-dimethyl-1, 6-dioxaspiro(4.5)dec-7-yl)ethyl)tetrahydro-2-hydroxy-4, 5-dimethoxy-3-methyl-, monoammonium salt, (2R, 3S, 4S, 5R, 6S)-

Smiles: N.C[C@]1(O)O[C@H]([C@H]2C[C@H](O[C@@H]3C[C@H](OC)[C@@H](OC)[C@H](C)O3)[C@@H](O2)[C@]2(C)CC[C@@H](O2)[C@]2(C)CC[C@]3(C[C@H](O)[C@@H](C)[C@H](O3)[C@@H](C)[C@@H]3O[C@](O)(CC(O)=O)[C@@H](C)[C@H](OC)[C@H]3OC)O2)[C@@H](C)C[C@H]1C

InChiKey: WQGJEAMPBSZCIF-HKSLRPGUSA-N

InChi: InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50;/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50);1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. McDougald LR, et al. Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.Avian Dis. 1990 Jul-Sep;34(3):634-8.
2. Gao X, et al.Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.Toxicol In Vitro. 2018 Aug;50:190-200.

Products are for research use only. Not for human use.