Catalog No. Size PriceQuantity
M12929-2 2mg solid $195
M12929-10 10mg solid $675


RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).

Product information

CAS Number: 355406-76-7

Molecular Weight: 428.45

Formula: C26H21FN2O3

Chemical Name: N-(3-(Benzylamino)-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide

Smiles: CC(=O)N(CC1C=CC(F)=CC=1)C1=C(NCC2C=CC=CC=2)C(=O)C2=CC=CC=C2C1=O


InChi: InChI=1S/C26H21FN2O3/c1-17(30)29(16-19-11-13-20(27)14-12-19)24-23(28-15-18-7-3-2-4-8-18)25(31)21-9-5-6-10-22(21)26(24)32/h2-14,28H,15-16H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RIPGBM causes caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 and acting as a molecular switch. It reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex .


  1. Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.

Products are for research use only. Not for human use.

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