VU 0365114

Catalog No. Size PriceQuantity
M12987-2 Contact for quotation $100
M12987-10 Contact for quotation $100


VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM.

Product information

CAS Number: 1208222-39-2

Molecular Weight: 397.35

Formula: C22H14F3NO3

Chemical Name: 1-({[1,1'-biphenyl]-4-yl}methyl)-5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione

Smiles: O=C1C2=CC(=CC=C2N(CC2C=CC(=CC=2)C2C=CC=CC=2)C1=O)OC(F)(F)F


InChi: InChI=1S/C22H14F3NO3/c23-22(24,25)29-17-10-11-19-18(12-17)20(27)21(28)26(19)13-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-12H,13H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 77.5 mg/mL (195.04 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Bridges TM, et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22.

Products are for research use only. Not for human use.

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