Thalidomide-O-PEG2-propargyl


Catalog No. Size PriceQuantity
M13015-2 Contact sales@xcessbio.com for quotation $100
M13015-10 Contact sales@xcessbio.com for quotation $100

Description

Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

Product information

CAS Number: 2098487-52-4

Molecular Weight: 400.38

Formula: C20H20N2O7

Synonym:

E3 ligase Ligand-Linker Conjugates 32

Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-4-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}-2,3-dihydro-1H-isoindole-1,3-dione

Smiles: C#CCOCCOCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

InChiKey: XJWGDRINRIEEJD-UHFFFAOYSA-N

InChi: InChI=1S/C20H20N2O7/c1-2-8-27-9-10-28-11-12-29-15-5-3-4-13-17(15)20(26)22(19(13)25)14-6-7-16(23)21-18(14)24/h1,3-5,14H,6-12H2,(H,21,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 120 mg/mL (299.72 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed