BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells.
Molecular Weight: 574.87
Chemical Name: dodecyl (4R)-4-[(1R,3aS,3bS,5aR,7R,9aS,9bS,11S,11aR)-3a,3b,5a,9b-tetrahydrogenio-7,11-dihydroxy-9a,11a-dimethyl-10-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) treatment induces cell death in LPS-primed THP-1-Cas9 cells.
- Alimov I, et al. Bile acid analogues are activators of pyrin inflammasome. J Biol Chem. 2019 Mar 8;294(10):3359-3366.
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