VH032-thiol-C6-NH2


Catalog No. Size PriceQuantity
M13052-2 Contact sales@xcessbio.com for quotation $100
M13052-10 Contact sales@xcessbio.com for quotation $100

Description

VH032-thiol-C6-NH2 (VHL Ligand-Linker Conjugates 14) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.

Product information

CAS Number: 2098836-63-4

Molecular Weight: 589.81

Formula: C29H43N5O4S2

Chemical Name: (2S,4R)-1-[(2R)-3-[(6-aminohexyl)sulfanyl]-2-acetamido-3-methylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

Smiles: CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1)C1SC=NC=1C)C(C)(C)SCCCCCCN

InChiKey: GRWPLYITJSUPHS-RMTZWNOUSA-N

InChi: InChI=1S/C29H43N5O4S2/c1-19-25(39-18-32-19)22-11-9-21(10-12-22)16-31-27(37)24-15-23(36)17-34(24)28(38)26(33-20(2)35)29(3,4)40-14-8-6-5-7-13-30/h9-12,18,23-24,26,36H,5-8,13-17,30H2,1-4H3,(H,31,37)(H,33,35)/t23-,24+,26-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

VH032-thiol-C6-NH2 (VHL Ligand-Linker Conjugates 14) is a compound binding to BRD4, used to inhibit BRD4 based on PROTAC.

References:

  1. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Products are for research use only. Not for human use.

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