c(phg-isoDGR-(NMe)k) TFA


Catalog No. Size PriceQuantity
M13057-2 2 mg solid $640
M13057-10 10 mg solid $2,425
M13057-C Contact sales@xchem.com for quotation $100

Description

c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM.

Product information

Molecular Weight: 717.69

Formula: C29H42F3N9O9

Chemical Name: (5S,8R,11R,14S)-8-(4-aminobutyl)-5-(3-carbamimidamidopropyl)-7-methyl-3,6,9,12,16-pentaoxo-11-phenyl-1,4,7,10,13-pentaazacyclohexadecane-14-carboxylic acid; trifluoroacetic acid

Smiles: CN1[C@H](CCCCN)C(=O)N[C@H](C2C=CC=CC=2)C(=O)N[C@@H](CC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C1=O)C(O)=O.OC(=O)C(F)(F)F

InChiKey: ILAYWYHCAONWQF-DIKLDQRVSA-N

InChi: InChI=1S/C27H41N9O7.C2HF3O2/c1-36-19(11-5-6-12-28)23(39)35-22(16-8-3-2-4-9-16)24(40)34-18(26(42)43)14-20(37)32-15-21(38)33-17(25(36)41)10-7-13-31-27(29)30;3-2(4,5)1(6)7/h2-4,8-9,17-19,22H,5-7,10-15,28H2,1H3,(H,32,37)(H,33,38)(H,34,40)(H,35,39)(H,42,43)(H4,29,30,31);(H,6,7)/t17-,18-,19+,22+;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (348.34 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

c(phg-isoDGR-(NMe)k) TFA is trimerized with the chelator TRAP and used as a positron-emission tomography tracer for monitoring α5β1 integrin expression in a M21 mouse xenograft.

References:

  1. Kapp TG, et al. N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. J Med Chem. 2018 Mar 22;61(6):2490-2499.

Products are for research use only. Not for human use.

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