DAGLβ-IN-1

DAGLβ-IN-1 is an inhibitor of diacylglycerol lipase-β (DAGLβ), serves as a versatile intermediate for the design of DAGL-tailored activity-based probes.

Product information

CAS Number: 1402612-61-6

Molecular Weight: 561.60

Formula: C28H34F3N5O4

Chemical Name: tert-butyl N-{5-[(2-phenylethyl)({4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-1-carbonyl})amino]pentyl}carbamate

Smiles: CC(C)(C)OC(=O)NCCCCCN(CCC1C=CC=CC=1)C(=O)N1C=C(N=N1)C1=CC=C(C=C1)OC(F)(F)F

InChiKey: NUWWTGPNHRKNPN-UHFFFAOYSA-N

InChi: InChI=1S/C28H34F3N5O4/c1-27(2,3)40-25(37)32-17-8-5-9-18-35(19-16-21-10-6-4-7-11-21)26(38)36-20-24(33-34-36)22-12-14-23(15-13-22)39-28(29,30)31/h4,6-7,10-15,20H,5,8-9,16-19H2,1-3H3,(H,32,37)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Diacylglycerol lipase-β (DAGLβ) is a principal biosynthetic enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG).

References:

1. Ku-Lung Hsu, et al. Development and Optimization of Piperidyl-1,2,3-Triazole Ureas as Selective Chemical Probes of Endocannabinoid Biosynthesis. J Med Chem . 2013 Nov 14;56(21):8257-69.
2. Tiziana Bisogno, et al. Cloning of the First sn1-DAG Lipases Points to the Spatial and Temporal Regulation of Endocannabinoid Signaling in the Brain. J Cell Biol. 2003 Nov 10;163(3):463-8.

Products are for research use only. Not for human use.