Propargyl-PEG6-alcohol


Catalog No. Size PriceQuantity
M13103-2 Contact sales@xcessbio.com for quotation $100
M13103-10 Contact sales@xcessbio.com for quotation $100

Description

Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 944560-99-0

Molecular Weight: 320.38

Formula: C15H28O7

Chemical Name: 3,6,9,12,15,18-hexaoxahenicos-20-yn-1-ol

Smiles: C#CCOCCOCCOCCOCCOCCOCCO

InChiKey: USWWECGLRVWCRJ-UHFFFAOYSA-N

InChi: InChI=1S/C15H28O7/c1-2-4-17-6-8-19-10-12-21-14-15-22-13-11-20-9-7-18-5-3-16/h1,16H,3-15H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Goswami LN, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery. Org Biomol Chem. 2013 Feb 21;11(7):1116-26.

Products are for research use only. Not for human use.

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