Boc-C1-PEG3-C4-OBn


Catalog No. Size PriceQuantity
M13120-2 2mg solid $80
M13120-10 10mg solid $240

Description

Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Product information

CAS Number: 2381196-81-0

Molecular Weight: 410.54

Formula: C23H38O6

Chemical Name: tert-butyl 1-phenyl-2,9,12,15-tetraoxaheptadecan-17-oate

Smiles: CC(C)(C)OC(=O)COCCOCCOCCCCCCOCC1C=CC=CC=1

InChiKey: RBTVTEMDPRBJLY-UHFFFAOYSA-N

InChi: InChI=1S/C23H38O6/c1-23(2,3)29-22(24)20-28-18-17-26-16-15-25-13-9-4-5-10-14-27-19-21-11-7-6-8-12-21/h6-8,11-12H,4-5,9-10,13-20H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTACDegrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.

Products are for research use only. Not for human use.

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