Br-Boc-C2-azido


Catalog No. Size PriceQuantity
M13154-2 Contact sales@xcessbio.com for quotation $100
M13154-10 Contact sales@xcessbio.com for quotation $100

Description

Br-Boc-C2-azido is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1120364-53-5

Molecular Weight: 236.07

Formula: C6H10BrN3O2

Chemical Name: 2-azidoethyl 2-bromo-2-methylpropanoate

Smiles: CC(C)(Br)C(=O)OCCN=[N+]=[N-]

InChiKey: OYSXPOJKJKBNSG-UHFFFAOYSA-N

InChi: InChI=1S/C6H10BrN3O2/c1-6(2,7)5(11)12-4-3-9-10-8/h3-4H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Products are for research use only. Not for human use.

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