Catalog No. Size PriceQuantity
M13155-2 2mg solid $100
M13155-10 10mg solid $300


PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

Product information

CAS Number: 2170608-82-7

Molecular Weight: 349.43

Formula: C20H23N5O

Chemical Name: 6-(4-{2-[4-(propan-2-yl)phenyl]acetyl}piperazin-1-yl)pyridazine-3-carbonitrile

Smiles: CC(C)C1=CC=C(CC(=O)N2CCN(CC2)C2C=CC(C#N)=NN=2)C=C1


InChi: InChI=1S/C20H23N5O/c1-15(2)17-5-3-16(4-6-17)13-20(26)25-11-9-24(10-12-25)19-8-7-18(14-21)22-23-19/h3-8,15H,9-13H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 75 mg/mL (214.64 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PZ-2891 inhibits mouse pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 48.7±5.1 nM, 1.0±0.1 nM, and 1.9±0.2 nM, respectively.


  1. Lalit, Kumar, Sharma, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration.[J]. Nature communications, 2018.

Products are for research use only. Not for human use.

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