Thalidomide-NH-PEG4-COOH


Catalog No. Size PriceQuantity
M13171-2 2mg solid $170
M13171-10 10mg solid $555

Description

Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.

Product information

CAS Number: 2412056-48-3

Molecular Weight: 521.52

Formula: C24H31N3O10

Chemical Name: 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid

Smiles: OC(=O)CCOCCOCCOCCOCCNC1C=C2C(=CC=1)C(=O)N(C1CCC(=O)NC1=O)C2=O

InChiKey: LKZFZWXIYMGKMH-UHFFFAOYSA-N

InChi: InChI=1S/C24H31N3O10/c28-20-4-3-19(22(31)26-20)27-23(32)17-2-1-16(15-18(17)24(27)33)25-6-8-35-10-12-37-14-13-36-11-9-34-7-5-21(29)30/h1-2,15,19,25H,3-14H2,(H,29,30)(H,26,28,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Thalidomide-NH-PEG4-COOH (S13) is the E3 ligase ligand-linker conjugate of dCBP-1.

References:

  1. Raghu Vannam, et al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31;S2451-9456(20)30513-4.

Products are for research use only. Not for human use.

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