Description
Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 2055022-35-8
Molecular Weight: 452.54
Formula: C21H40O10
Chemical Name: 3,6,9,12,15,18,21,24,27-nonaoxatriacont-29-yn-1-ol
Smiles: C#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChiKey: FBQGPFAGZKPHQT-UHFFFAOYSA-N
InChi: InChI=1S/C21H40O10/c1-2-4-23-6-8-25-10-12-27-14-16-29-18-20-31-21-19-30-17-15-28-13-11-26-9-7-24-5-3-22/h1,22H,3-21H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1.
Products are for research use only. Not for human use.
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