Description
Br-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 177987-04-1
Molecular Weight: 496.23
Formula: C16H32Br2O7
Chemical Name: 1,23-dibromo-3,6,9,12,15,18,21-heptaoxatricosane
Smiles: BrCCOCCOCCOCCOCCOCCOCCOCCBr
InChiKey: WZVUWDFPUXHBBR-UHFFFAOYSA-N
InChi: InChI=1S/C16H32Br2O7/c17-1-3-19-5-7-21-9-11-23-13-15-25-16-14-24-12-10-22-8-6-20-4-2-18/h1-16H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Products are for research use only. Not for human use.
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