NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.
CAS Number: 2438637-61-5
Molecular Weight: 545.36
Chemical Name: 4-[(2,6-dichlorophenyl)sulfanyl]-3-(5,6-dimethoxy-2,3-dihydro-1H-isoindole-2-carbonyl)-6-(trifluoromethyl)-1,2-dihydropyridin-2-one
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells.
- Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.
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