NRX-252262


Catalog No. Size PriceQuantity
M13192-2 2mg solid $170
M13192-10 10mg solid $555

Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.

Product information

CAS Number: 2438637-61-5

Molecular Weight: 545.36

Formula: C23H17Cl2F3N2O4S

Chemical Name: 4-[(2,6-dichlorophenyl)sulfanyl]-3-(5,6-dimethoxy-2,3-dihydro-1H-isoindole-2-carbonyl)-6-(trifluoromethyl)-1,2-dihydropyridin-2-one

Smiles: COC1C=C2CN(CC2=CC=1OC)C(=O)C1=C(C=C(NC1=O)C(F)(F)F)SC1C(Cl)=CC=CC=1Cl

InChiKey: SPAYLOCXFWJEBL-UHFFFAOYSA-N

InChi: InChI=1S/C23H17Cl2F3N2O4S/c1-33-15-6-11-9-30(10-12(11)7-16(15)34-2)22(32)19-17(8-18(23(26,27)28)29-21(19)31)35-20-13(24)4-3-5-14(20)25/h3-8H,9-10H2,1-2H3,(H,29,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells.

References:

  1. Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.

Products are for research use only. Not for human use.

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