Levothyroxine acyl glucuronide


Catalog No. Size PriceQuantity
M13223-2 Contact sales@xcessbio.com for quotation $100
M13223-10 Contact sales@xcessbio.com for quotation $100

Description

Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), an endogenous metabolite, is the acyl glucuronide formation of thyroxine (T4).

Product information

CAS Number: 909880-81-5

Molecular Weight: 952.99

Formula: C21H19I4NO10

Synonym:

Thyroxine acyl-β-D-glucuronide

Chemical Name: (2S,3S,4S,5R,6S)-6-{[(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoyl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid

Smiles: N[C@@H](CC1=CC(I)=C(OC2C=C(I)C(O)=C(I)C=2)C(I)=C1)C(=O)O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O

InChiKey: HMTFXPJOBPIOIN-DKBYMCRTSA-N

InChi: InChI=1S/C21H19I4NO10/c22-8-4-7(5-9(23)13(8)27)34-17-10(24)1-6(2-11(17)25)3-12(26)20(33)36-21-16(30)14(28)15(29)18(35-21)19(31)32/h1-2,4-5,12,14-16,18,21,27-30H,3,26H2,(H,31,32)/t12-,14-,15-,16+,18-,21-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Levothyroxine acyl glucuronide is a metabolite of T4 glucuronides after hydrolysis with β-glucuronidase.

References:

  1. Tong Z, et al. In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2007 Dec;35(12):2203-10.

Products are for research use only. Not for human use.

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