Description
m-PEG6-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 125562-29-0
Molecular Weight: 359.25
Formula: C13H27BrO6
Chemical Name: 19-bromo-2,5,8,11,14,17-hexaoxanonadecane
Smiles: COCCOCCOCCOCCOCCOCCBr
InChiKey: GFRLIPYEIIWDJX-UHFFFAOYSA-N
InChi: InChI=1S/C13H27BrO6/c1-15-4-5-17-8-9-19-12-13-20-11-10-18-7-6-16-3-2-14/h2-13H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Jennifer Riggs-Sauthier, et al. Oligomer-antihistamine conjugates. WO2008112257A1.
Products are for research use only. Not for human use.
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