BI-167107


Catalog No. Size PriceQuantity
M13233-2 2mg solid $170
M13233-10 10mg solid $555

Description

BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM.

Product information

CAS Number: 1202235-68-4

Molecular Weight: 370.44

Formula: C21H26N2O4

Chemical Name: 5-hydroxy-8-(1-hydroxy-2-{[2-methyl-1-(2-methylphenyl)propan-2-yl]amino}ethyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one

Smiles: CC1C=CC=CC=1CC(C)(C)NCC(O)C1C=CC(O)=C2NC(=O)COC=12

InChiKey: NWQXBEWHTDRJIP-UHFFFAOYSA-N

InChi: InChI=1S/C21H26N2O4/c1-13-6-4-5-7-14(13)10-21(2,3)22-11-17(25)15-8-9-16(24)19-20(15)27-12-18(26)23-19/h4-9,17,22,24-25H,10-12H2,1-3H3,(H,23,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 75 mg/mL (202.46 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Compared to other βAR ligands, BI-167107 displays nanomolar affinities and slow off-rates.

References:

  1. Rasmussen SG, et al. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 2011 Jan 13;469(7329):175-80.

Products are for research use only. Not for human use.

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