m-PEG11-Amine


Catalog No. Size PriceQuantity
M13243-2 Contact sales@xcessbio.com for quotation $100
M13243-10 Contact sales@xcessbio.com for quotation $100

Description

m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 854601-60-8

Molecular Weight: 515.64

Formula: C23H49NO11

Chemical Name: 2,5,8,11,14,17,20,23,26,29,32-undecaoxatetratriacontan-34-amine

Smiles: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

InChiKey: SWAJVHMMXALQKJ-UHFFFAOYSA-N

InChi: InChI=1S/C23H49NO11/c1-25-4-5-27-8-9-29-12-13-31-16-17-33-20-21-35-23-22-34-19-18-32-15-14-30-11-10-28-7-6-26-3-2-24/h2-24H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

References:

  1. Erwin R. Boghaert, et al. Anti-egfr antibody drug conjugates. WO2017214282A1.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed