Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester


Catalog No. Size PriceQuantity
M13249-2 Contact sales@xcessbio.com for quotation $100
M13249-10 Contact sales@xcessbio.com for quotation $100

Description

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Product information

Molecular Weight: 807.76

Formula: C38H42F5N5O9

Chemical Name: 2,3,4,5,6-pentafluorophenyl 6-(1-azido-3,6,9,12-tetraoxapentadecan-15-amido)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoate

Smiles: [N-]=[N+]=NCCOCCOCCOCCOCCC(=O)NCCCCC(NC(=O)OCC1C2=CC=CC=C2C2C=CC=CC=21)C(=O)OC1C(F)=C(F)C(F)=C(F)C=1F

InChiKey: NOHZZMMQTNBKSR-UHFFFAOYSA-N

InChi: InChI=1S/C38H42F5N5O9/c39-31-32(40)34(42)36(35(43)33(31)41)57-37(50)29(47-38(51)56-23-28-26-9-3-1-7-24(26)25-8-2-4-10-27(25)28)11-5-6-13-45-30(49)12-15-52-17-19-54-21-22-55-20-18-53-16-14-46-48-44/h1-4,7-10,28-29H,5-6,11-23H2,(H,45,49)(H,47,51)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

References:

  1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Products are for research use only. Not for human use.

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