Description
Tertatolol is a potent antagonist of beta-adrenoceptor and 5-HT receptor, with unique renal vasodilatatory effects.
Product information
CAS Number: 83688-84-0
Molecular Weight: 295.44
Formula: C16H25NO2S
Synonym:
Racemic Tertatolol
dl-Tertatolol
Chemical Name: 1-(tert-butylamino)-3-(3,4-dihydro-2H-1-benzothiopyran-8-yloxy)propan-2-ol
Smiles: CC(C)(C)NCC(O)COC1C=CC=C2CCCSC2=1
InChiKey: HTWFXPCUFWKXOP-UHFFFAOYSA-N
InChi: InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
In serum-free media, tertatolol does not significantly alter the incorporation of 3H-thymidine after 28 h of incubation in human mesangial cell (HMC). In the presence of 1% serum, tertatolol significantly reduces 3H-thymidine incorporation. Tertatolol also inhibits 3H incorporation when PDGF and thrombin are used as the stimulus. Tertatolol inhibits the reduction in planar surface area of HMC induced by angiotensin II. The inhibitory effect of tertatolol on HMC proliferation is also potentiated by ritanserin and MDL 72222, 5HT2 and 5HT3 antagonists, respectively.
References:
- Shultz P, et al. Tertatolol: a beta-blocker with unique effects on human glomerular cell function. Cardiology. 1993;83 Suppl 1:51-6.
Products are for research use only. Not for human use.
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