Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM.
CAS Number: 59143-60-1
Molecular Weight: 478.81
Chemical Name: zinc(2+) (6R,7R)-3-[(acetyloxy)methyl]-7-[(5R)-5-amino-5-carboxylatopentanamido]-6-hydrogenio-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 5 mg/mL (10.44 mM; ultrasonic and adjust pH to 3 with 1M HCl).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 ± 0.1 μM, 200-fold more potent than Na+ salt form of Cephalosporin C (ICC50CC-Na = 213 ± 30 μM).
- Seamon KJ, et al. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20(6):801-9.
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