Cephalosporin C zinc salt

Catalog No. Size PriceQuantity
M13401-2 2mg solid $85
M13401-10 10mg solid $255


Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM.

Product information

CAS Number: 59143-60-1

Molecular Weight: 478.81

Formula: C16H19N3O8SZn

Chemical Name: zinc(2+) (6R,7R)-3-[(acetyloxy)methyl]-7-[(5R)-5-amino-5-carboxylatopentanamido]-6-hydrogenio-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Smiles: [Zn+2].CC(=O)OCC1CS[C@@H]2[C@H](NC(=O)CCC[C@@H](N)C([O-])=O)C(=O)N2C=1C([O-])=O


InChi: InChI=1S/C16H21N3O8S.Zn/c1-7(20)27-5-8-6-28-14-11(13(22)19(14)12(8)16(25)26)18-10(21)4-2-3-9(17)15(23)24;/h9,11,14H,2-6,17H2,1H3,(H,18,21)(H,23,24)(H,25,26);/q;+2/p-2/t9-,11-,14-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (10.44 mM; ultrasonic and adjust pH to 3 with 1M HCl).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 ± 0.1 μM, 200-fold more potent than Na+ salt form of Cephalosporin C (ICC50CC-Na = 213 ± 30 μM).


  1. Seamon KJ, et al. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20(6):801-9.

Products are for research use only. Not for human use.

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