Ro-24-0238


Catalog No. Size PriceQuantity
M13424-2 Contact sales@xcessbio.com for quotation $100
M13424-10 Contact sales@xcessbio.com for quotation $100

Description

Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF.

Product information

CAS Number: 120555-31-9

Molecular Weight: 420.59

Formula: C27H36N2O2

Chemical Name: (2E,4E)-5-(4-methoxyphenyl)-N-[(2R)-5-(pyridin-3-yl)pentan-2-yl]deca-2,4-dienamide

Smiles: CCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCC1C=NC=CC=1)/C1C=CC(=CC=1)OC

InChiKey: HLCHRSFXEXAMLU-YDQNRGGDSA-N

InChi: InChI=1S/C27H36N2O2/c1-4-5-6-13-24(25-16-18-26(31-3)19-17-25)14-8-15-27(30)29-22(2)10-7-11-23-12-9-20-28-21-23/h8-9,12,14-22H,4-7,10-11,13H2,1-3H3,(H,29,30)/b15-8+,24-14+/t22-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Pretreatment with 3 mg/kg Ro 24-0238 and 3 mg/kg WEB 2086 decreases the accumulation of neutrophils within the mucosa in rats.

References:

  1. Will PC, et al. Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. Agents Actions. 1991 Sep;34(1-2):181-4.

Products are for research use only. Not for human use.

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