CL075


Catalog No. Size PriceQuantity
M13573-2 2mg solid $845
M13573-10 10mg solid $3,380

Description

CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.

Product information

CAS Number: 256922-53-9

Molecular Weight: 243.33

Formula: C13H13N3S

Synonym:

3M002

Chemical Name: 2-propyl-[1,3]thiazolo[4,5-c]quinolin-4-amine

Smiles: CCCC1=NC2=C(S1)C1=CC=CC=C1N=C2N

InChiKey: NFYMGJSUKCDVJR-UHFFFAOYSA-N

InChi: InChI=1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 22 mg/mL (90.41 mM; Need ultrasonic and warming).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CL075 (2 μM; 4 h) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes. CL075 (2 μM; 48 h) induces the total IgM production and cell proliferation in rabbit splenocytes. CL075 (2 μM; 7 h) activates the rabTLR8 in 293 cells.

In Vivo:

CL075 (5 μM (0.5 mL); s.c.) activates a mild antigen-specific antibody response in rabbits.

References:

  1. Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9.
  2. Spranger S, et, al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010 Jul 1;185(1):738-47.
  3. Maalej KM, et, al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015 Jun;97(6):1081-7.

Products are for research use only. Not for human use.

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