VU0155041 sodium


Catalog No. Size PriceQuantity
M13583-2 Contact sales@xcessbio.com for quotation $100
M13583-10 Contact sales@xcessbio.com for quotation $100

Description

VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).

Product information

CAS Number: 1259372-69-4

Molecular Weight: 338.16

Formula: C14H14Cl2NNaO3

Chemical Name: sodium (1S,2R)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylate

Smiles: O=C(O[Na])[C@H]1CCCC[C@H]1C(=O)NC1C=C(Cl)C=C(Cl)C=1

InChiKey: ZFDOLOCYGVTGDQ-LYCTWNKOSA-M

InChi: InChI=1S/C14H15Cl2NO3.Na/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20;/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20);/q;+1/p-1/t11-,12+;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: 10 mM in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons.

In Vivo:

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats. VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats.

References:

  1. Mironov AA, Beznoussenko GV, Nicoziani P, Martella O, Trucco A, Kweon H, Giandomenico DD, Polishchuk RS, Fusella A, Lupetti P, Berger EG, Geerts WJC, Koster AJ, Burger KNJ, Luini A (2001). "Small cargo proteins and large aggregates can traverse the Golgi by a common mechanism without leaving the lumen of cisternae". JCB 155 (7): 1225-38.

Products are for research use only. Not for human use.

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