Glycyl-glutamine


Catalog No. Size PriceQuantity
M13600-2 2mg solid $80
M13600-10 10mg solid $240

Description

Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln).

Product information

CAS Number: 13115-71-4

Molecular Weight: 203.20

Formula: C7H13N3O4

Synonym:

Glycyl-L-glutamine

Chemical Name: (2S)-2-(2-aminoacetamido)-4-carbamoylbutanoic acid

Smiles: NC(=O)CC[C@H](NC(=O)CN)C(O)=O

InChiKey: PNMUAGGSDZXTHX-BYPYZUCNSA-N

InChi: InChI=1S/C7H13N3O4/c8-3-6(12)10-4(7(13)14)1-2-5(9)11/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14)/t4-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 62.5 mg/mL (307.58 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide. Glycyl-glutamine (Glycyl-L-glutamine) has an advantage over free glutamine (Gln) as growth factors for cell culture during both autoclaving and storage.

In Vivo:

Glycyl-glutamine (Glycyl-L-glutamine) (0.3, 0.6, 1.0 and 10.0 nM) can dose-dependently inhibit beta-End-(1-31)-induced hypotension in pentobarbital-anesthetized rats.

References:

  1. Unal CB1, et al. Beta-endorphin-induced cardiorespiratory depression is inhibited by glycyl-L-glutamine, a dipeptide derived from beta-endorphin processing.J Pharmacol Exp Ther. 1994 Nov;271(2):952-8
  2. Roth E, et al. Influence of two glutamine-containing dipeptides on growth of mammalian cells.In Vitro Cell Dev Biol. 1988 Jul;24(7):696-8.

Products are for research use only. Not for human use.

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