NBQX disodium


Catalog No. Size PriceQuantity
M13651-2 Contact sales@xcessbio.com for quotation $100

Description

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.

Product information

CAS Number: 479347-86-9

Molecular Weight: 380.24

Formula: C12H6N4Na2O6S

Synonym:

FG9202 disodium

Chemical Name: disodium 6-nitro-2,3-dioxo-7-sulfamoyl-1H,2H,3H,4H-benzo[f]quinoxaline-1,4-diide

Smiles: [Na+].[Na+].NS(=O)(=O)C1=CC=CC2=C1C(=CC1[N-]C(=O)C(=O)[N-]C=12)[N+]([O-])=O

InChiKey: XFHCQLPOJLVQQE-UHFFFAOYSA-L

InChi: InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H4,13,14,15,17,18,21,22);;/q;2*+1/p-2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.

In Vivo:

NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.

References:

  1. Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19(8):1174-84.
  2. Wen Chen, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016 Nov 23;11(11):e0166672.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed