Description
Beta-defensin 1, pig is an antimicrobial peptide found primarily in tongue mucosa of pig. Beta-defensin 1, pig is active against bacteria such as Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, Bordetella pertussis and Candida albicans.
Product information
Chemical Name: Beta-defensin 1, pig
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Expression of beta-defensin (pBD-1) mRNA increased from the proximal to the distal part of the intestine whereas pBD-2 expression decreased. The main gene expression sites for pBD-2 are kidney and liver, whereas pBD-1 is mainly expressed in tongue. An eight-fold increase in pBD-1 mRNA expression is observed upon S. typhimurium infection in the porcine intestinal cell line IPEC J2. Porcine beta-defensin 1 (pBD-1) also has immunomodulatory activity in porcine peripheral blood mononuclear cells and lymph node cells.
In Vivo:
Resistance against respiratory infection with B. pertussis in older piglets is associated with the presence of Porcine beta-defensin 1 (pBD-1) in the upper respiratory tract. Furthermore, treatment with pBD-1 conferred complete protection of newborn piglets from intrapulmonary infection with B. pertussis.
Products are for research use only. Not for human use.
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