Cyclo(RGDyK)


Catalog No. Size PriceQuantity
M13675-2 Contact sales@xcessbio.com for quotation $100

Description

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Product information

CAS Number: 217099-14-4

Molecular Weight: 619.67

Formula: C27H41N9O8

Chemical Name: 2-[(2S, 5R, 8S, 11S)-8-(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-5-[(4-hydroxyphenyl)methyl]-3, 6, 9, 12, 15-pentaoxo-1, 4, 7, 10, 13-pentazacyclopentadec-2-yl]acetic acid

Smiles: NC(N)=NCCCC1NC(=O)C(CCCCN)NC(=O)C(CC2C=CC(O)=CC=2)NC(=O)C(CC(O)=O)NC(=O)CNC1=O

InChiKey: LAROZEWEPNAWMD-UHFFFAOYSA-N

InChi: InChI=1S/C27H41N9O8/c28-10-2-1-4-18-24(42)34-17(5-3-11-31-27(29)30)23(41)32-14-21(38)33-20(13-22(39)40)26(44)36-19(25(43)35-18)12-15-6-8-16(37)9-7-15/h6-9,17-20,37H,1-5,10-14,28H2,(H,32,41)(H,33,38)(H,34,42)(H,35,43)(H,36,44)(H,39,40)(H4,29,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM).

References:

  1. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36.

Products are for research use only. Not for human use.

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