Description
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 2055014-96-3
Molecular Weight: 492.60
Formula: C24H44O10
Chemical Name: tert-butyl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-ynoate
Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCC#C
InChiKey: IGEMRRCREJIMCQ-UHFFFAOYSA-N
InChi: InChI=1S/C24H44O10/c1-5-7-26-9-11-28-13-15-30-17-19-32-21-22-33-20-18-31-16-14-29-12-10-27-8-6-23(25)34-24(2,3)4/h1H,6-22H2,2-4H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Noah Bell, et al. Compounds and methods for inhibiting phosphate transport. WO2012054110A2.
Products are for research use only. Not for human use.
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