Eniluracil


Catalog No. Size PriceQuantity
M13769-2 2mg solid $90
M13769-10 10mg solid $270

Description

Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity.

Product information

CAS Number: 59989-18-3

Molecular Weight: 136.11

Formula: C6H4N2O2

Synonym:

5-Ethynyluracil

GW776C85

Chemical Name: 5-ethynyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Smiles: C#CC1=CNC(=O)NC1=O

InChiKey: JOZGNYDSEBIJDH-UHFFFAOYSA-N

InChi: InChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 41.67 mg/mL (306.15 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Schilsky RL, et al. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.

Products are for research use only. Not for human use.

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