XEN723


Catalog No. Size PriceQuantity
M13782-2 Contact sales@xcessbio.com for quotation $100
M13782-10 Contact sales@xcessbio.com for quotation $100

Description

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.

Product information

CAS Number: 1072803-08-7

Molecular Weight: 425.48

Formula: C21H20FN5O2S

Chemical Name: 2-{3-[(4-fluorophenyl)methyl]-2-oxoimidazolidin-1-yl}-4-methyl-N-[(pyridin-3-yl)methyl]-1,3-thiazole-5-carboxamide

Smiles: CC1N=C(SC=1C(=O)NCC1C=NC=CC=1)N1CCN(CC2C=CC(F)=CC=2)C1=O

InChiKey: OVFKEMNMAWPWAV-UHFFFAOYSA-N

InChi: InChI=1S/C21H20FN5O2S/c1-14-18(19(28)24-12-16-3-2-8-23-11-16)30-20(25-14)27-10-9-26(21(27)29)13-15-4-6-17(22)7-5-15/h2-8,11H,9-10,12-13H2,1H3,(H,24,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL (235.03 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit.

References:

  1. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.

Products are for research use only. Not for human use.

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