Sirtuin modulator 1

Sirtuin modulator 1 is a modulator of SIRTl, a homolog of SIRT3, with EC1.5 of < 1 μM, extracted from patent WO 2010071853 A1, Compound No.4.

Product information

CAS Number: 2070015-26-6

Molecular Weight: 606.20

Formula: C31H32ClN5O2S2

Chemical Name: 5-(3-methoxypropyl)-2-phenyl-N-(2-{6-[(pyrrolidin-1-yl)methyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-1,3-thiazole-4-carboxamide; chlorohydrogen

Smiles: Cl.COCCCC1SC(=NC=1C(=O)NC1=CC=CC=C1C1=NC2C=C(CN3CCCC3)C=NC=2S1)C1C=CC=CC=1

InChiKey: LGRBDTOIPNDWMN-UHFFFAOYSA-N

InChi: InChI=1S/C31H31N5O2S2.ClH/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36;/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 12.5 mg/mL (20.62 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Thiazolopyridine sirtuin modulating compounds. WO 2010071853 A1

Products are for research use only. Not for human use.