Euphorbia Factor L2

Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway.

Product information

CAS Number: 218916-51-9

Molecular Weight: 642.73

Formula: C38H42O9

Chemical Name: (1R,3E,5R,7S,9R,11R,12R,13S,14S)-1,11-bis(acetyloxy)-13-(benzoyloxy)-5,7,12-trihydrogenio-3,6,6,14-tetramethyl-10-methylidene-2-oxotricyclo[10.3.0.0⁵,⁷]pentadec-3-en-9-yl benzoate

Smiles: CC1(C)[C@@H]2C=C(C)C(=O)[C@]3(C[C@H](C)[C@H](OC(=O)C4C=CC=CC=4)[C@@H]3[C@@H](OC(C)=O)C(=C)[C@@H](C[C@H]12)OC(=O)C1C=CC=CC=1)OC(C)=O |c:4|

InChiKey: AFRGWGGHJYMSDU-NKGNXCQNSA-N

InChi: InChI=1S/C38H42O9/c1-21-18-28-29(37(28,6)7)19-30(45-35(42)26-14-10-8-11-15-26)23(3)33(44-24(4)39)31-32(46-36(43)27-16-12-9-13-17-27)22(2)20-38(31,34(21)41)47-25(5)40/h8-18,22,28-33H,3,19-20H2,1-2,4-7H3/b21-18-/t22-,28+,29-,30+,31+,32-,33-,38+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 83.33 mg/mL (129.65 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Lin M, et al. Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway. Acta Pharm Sin B. 2017 Jan;7(1):59-64.

Products are for research use only. Not for human use.