Description
Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.
Product information
CAS Number: 2434633-17-5
Molecular Weight: 462.54
Formula: C29H26N4O2
Chemical Name: 5-[8-({[1,1'-biphenyl]-4-yl}methoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]-N-ethylpyridine-2-carboxamide
Smiles: CC1N=C2C(=CC=CN2C=1C1=CN=C(C=C1)C(=O)NCC)OCC1=CC=C(C=C1)C1=CC=CC=C1
InChiKey: VNNXRQLFCKSSMH-UHFFFAOYSA-N
InChi: InChI=1S/C29H26N4O2/c1-3-30-29(34)25-16-15-24(18-31-25)27-20(2)32-28-26(10-7-17-33(27)28)35-19-21-11-13-23(14-12-21)22-8-5-4-6-9-22/h4-18H,3,19H2,1-2H3,(H,30,34)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Aβ42-IN-1 free base treatment shows that the CLint value is 84.7 µL/min/mg protein.
Products are for research use only. Not for human use.
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