CBP/p300-IN-1


Catalog No. Size PriceQuantity
M13998-2 2mg solid $170
M13998-10 10mg solid $555

Description

CBP/p300-IN-1 is a CBP/EP300 bromodomain inhibitor.

Product information

CAS Number: 2443789-32-8

Molecular Weight: 426.44

Formula: C23H23FN2O5

Chemical Name: tert-butyl 3-(1-acetyl-5-methoxy-1H-indole-3-amido)-4-fluorobenzoate

Smiles: CC(=O)N1C=C(C2=CC(=CC=C12)OC)C(=O)NC1C=C(C=CC=1F)C(=O)OC(C)(C)C

InChiKey: BNTANBUTBDVIHY-UHFFFAOYSA-N

InChi: InChI=1S/C23H23FN2O5/c1-13(27)26-12-17(16-11-15(30-5)7-9-20(16)26)21(28)25-19-10-14(6-8-18(19)24)22(29)31-23(2,3)4/h6-12H,1-5H3,(H,25,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (146.56 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Xiang Q, et al. Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. Eur J Med Chem. 2018 Mar 10;147:238-252.

Products are for research use only. Not for human use.

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