INCB3344 R-isomer


Catalog No. Size PriceQuantity
M14106-2 Contact sales@xcessbio.com for quotation $100

Description

INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.

Product information

Molecular Weight: 577.59

Formula: C29H34F3N3O6

Chemical Name: N-[(3S,4S)-4-ethoxy-1-[(1s,4s)-4-(2H-1,3-benzodioxol-5-yl)-1-hydrogenio-4-hydroxycyclohexyl]pyrrolidin-3-yl]-2-{[3-(trifluoromethyl)phenyl]formamido}acetamide

Smiles: CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)C1=CC(=CC=C1)C(F)(F)F)[C@@H]1CC[C@](O)(CC1)C1=CC2OCOC=2C=C1

InChiKey: MZEOSVPWMSEFPW-LMHHSUHVSA-N

InChi: InChI=1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21-,22-,25-,28+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 106.5 mg/mL (184.39 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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