CN128 hydrochloride


Catalog No. Size PriceQuantity
M14165-2 2mg solid $130
M14165-10 10mg solid $390

Description

CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.

Product information

CAS Number: 1335282-05-7

Molecular Weight: 295.76

Formula: C15H18ClNO3

Synonym:

CN328

Chemical Name: 3-hydroxy-1-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-2-methyl-1,4-dihydropyridin-4-one; chlorohydrogen

Smiles: Cl.CC1=C(O)C(=O)C=CN1[C@H](CC1C=CC=CC=1)CO

InChiKey: CYFDKXLBMMEWNV-BTQNPOSSSA-N

InChi: InChI=1S/C15H17NO3.ClH/c1-11-15(19)14(18)7-8-16(11)13(10-17)9-12-5-3-2-4-6-12;/h2-8,13,17,19H,9-10H2,1H3;1H/t13-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 28.57 mg/mL (96.60 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CN128 hydrochloride possesses a high selectivity for iron(III) over others metals.

In Vivo:

CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat. The iron removal efficacies of CN128 displays a dose-dependent behavior. CN128 hydrochloride lacks genetic toxicity. CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg. CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats.

References:

  1. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.

Products are for research use only. Not for human use.

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