Description
GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
Product information
CAS Number: 2026635-66-3
Molecular Weight: 428.20
Formula: C17H10Cl2F3N5O
Chemical Name: (1R,2R)-2-(7-chloro-2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile
Smiles: N#C[C@@H]1C[C@H]1C1=C(Cl)C=CC2=NC(CN3N=C(C=C3Cl)C(F)(F)F)=CC(=O)N21
InChiKey: GPMGDUIAVSFGGH-WCBMZHEXSA-N
InChi: InChI=1S/C17H10Cl2F3N5O/c18-11-1-2-14-24-9(7-26-13(19)5-12(25-26)17(20,21)22)4-15(28)27(14)16(11)10-3-8(10)6-23/h1-2,4-5,8,10H,3,7H2/t8-,10+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
Products are for research use only. Not for human use.
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