Ponatinib D8


Catalog No. Size PriceQuantity
M14457-2 Contact sales@xcessbio.com for quotation $100

Description

Ponatinib D8 (AP24534 D8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

Product information

CAS Number: 1562993-37-6

Molecular Weight: 540.61

Formula: C29H27F3N6O

Chemical Name: 3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methyl-N-(4-{[4-methyl(2,2,3,3,5,5,6,6-²H₈)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl)benzamide

Smiles: [2H]C1([2H])N(CC2=CC=C(C=C2C(F)(F)F)NC(=O)C2=CC=C(C)C(=C2)C#CC2=CN=C3C=CC=NN23)C([2H])([2H])C([2H])([2H])N(C)C1([2H])[2H]

InChiKey: PHXJVRSECIGDHY-DHNBGMNGSA-N

InChi: InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)/i12D2,13D2,14D2,15D2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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